Short answer: yes, on a M4 Max 128 (128GB) at FP16/BF16. Long answer below.
Mixtral 8x7B has 46.7B parameters (MoE: 12.9B active per forward pass, but all 46.7B must fit in memory). At FP16 that's 93 GB of raw weights. Quantization shrinks that, but you also need budget for the KV cache (definition), framework overhead, and safety headroom. The rule of thumb: real usable budget on a card is roughly its nameplate VRAM minus 25%. That's how the table below was computed.
Smallest GPU that fits Mixtral 8x7B at any quant: M4 Max 128 at FP16/BF16.
Lossless inference needs 93 GB. Pick from 10 cards.
None of the showcase quants fit on a 24GB card. Step up.
Open the calculator pre-tuned for Mixtral 8x7B: ↗ /calc?model=mixtral-8x7b
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