Short answer: yes, on a M2 Max 64 (64GB) at FP16/BF16. Long answer below.
gpt-oss 20B has 20.9B parameters (MoE: 3.6B active per forward pass, but all 20.9B must fit in memory). At FP16 that's 42 GB of raw weights. Quantization shrinks that, but you also need budget for the KV cache (definition), framework overhead, and safety headroom. The rule of thumb: real usable budget on a card is roughly its nameplate VRAM minus 25%. That's how the table below was computed.
Smallest GPU that fits gpt-oss 20B at any quant: M2 Max 64 at FP16/BF16.
Lossless inference needs 42 GB. Pick from 17 cards.
Q5_K_M fits comfortably (14 GB weights).
Open the calculator pre-tuned for gpt-oss 20B: ↗ /calc?model=gpt-oss-20b
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